| Jim Johnson | Elbow | 60-day DL. On Double-A rehab assignment |
| Kevin Cash | Hamstring | 15-day DL. Out until at least late August |
| Hideki Okajima | Hamstring | 15-day DL. Out until at least late August |
| Jacoby Ellsbury | Side | 15-day DL. Might be out for the season |
| Dustin Pedroia | Foot | 15-day DL. Expected to return Aug. 17 vs. L.A. Angels |
| Kevin Youkilis | Thumb | 15-day DL. Out for the season |
| Manny Ramírez | Calf | 15-day DL. Might begin rehab assignment Aug. 18 |
| Jason Varitek | Foot | 15-day DL. Out until at least late August |
| Andy Pettitte | Groin | 15-day DL. Out until at least late August |
| LaTroy Hawkins | Shoulder | 15-day DL. Might be out for the season |
| Álex Rodríguez | Calf | Questionable for Aug. 17 vs. Detroit |
| Chien-Ming Wang | Shoulder | 60-day DL. Might be out for the season |
| Jesse Litsch | Hip | 15-day DL. Out for the season |
| David Purcey | Ankle | 15-day DL. Out until at least early September |
| David Eckstein | Calf | 15-day DL. Expected to begin Class A rehab assignment Aug. 18. Might return for Aug. 20-22 series at Milwaukee |
| Rod Barajas | Oblique | 15-day DL. May return Aug. 17 at Houston |
| Dustin McGowan | Shoulder | 60-day DL. Out for the season |
| Gregg Zaun | Shoulder | 60-day DL. Out for the season |
| Orlando Cabrera | Oblique | 15-day DL. Eligible to return Aug. 18 at Arizona |
| Bobby Jenks | Back | Questionable for Aug. 17 at Minnesota |
| Josh Fields | Hip | 60-day DL. On Class A rehab assignment |
| Nick Swisher | Forearm | Questionable for Aug. 17 vs. Detroit |
| Grady Sizemore | Knee | 60-day DL. Out for the season |
| Aaron Laffey | Arm | 15-day DL. On Class A rehab assignment |
| Joel Zumaya | Elbow | 60-day DL. Out for the season |
| Bobby Seay | Shoulder | 60-day DL. Out for the season |
| Édgar Rentería | Biceps | 15-day DL. Out until at least late August |
| Carlos Guillén | Leg | Questionable for Aug. 17 at N.Y. Yankees |
| Zach Miner | Elbow | 60-day DL. Out for the season |
| Magglio Ordóñez | Ankle | 15-day DL. Out until at least early September |
| Ross Gload | Groin | Questionable for Aug. 17 vs. L.A. Dodgers |
| Luke Hochevar | Elbow | 15-day DL. Out until at least early September |
| Gil Meche | Shoulder | 60-day DL. Out until at least early September |
| John Buck | Thumb | 15-day DL. Expected to begin Double-A rehab assignment Aug. 17 |
| David DeJesús | Thumb | 15-day DL. Out for the season |
| Joe Nathan | Elbow | 60-day DL. Out for the season |
| Carlos Gómez | Concussion | 15-day DL. On Triple-A rehab assignment |
| Justin Morneau | Concussion | 15-day DL. Out until at least late August |
| Kendry Morales | Ankle | 15-day DL. Out for the season |
| Jason Bulger | Shoulder | 15-day DL. On Triple-A rehab assignment |
| Francisco Rodríguez | Thumb | Likely out for the season |
| Rich Thompson | Shoulder | 15-day DL. Out until at least early September |
| Torii Hunter | Sickness | Probable for Aug. 17 start at Tampa Bay |
| Kelvim Escobar | Shoulder | 60-day DL. Out for the season |
| Ryan Sweeney | Knee | 60-day DL. Out for the season |
| Justin Duchscherer | Hip | 60-day DL. Out for the season |
| Rich Harden | Shoulder | 15-day DL. Might make Triple-A rehab start Aug. 17 |
| Eric Chávez | Neck | 60-day DL. Might be out for the season |
| Joey Devine | Elbow | 60-day DL. Might be out for the season |
| Jeff Weaver | Knee | 15-day DL. Out until at least late August |
| Mark Lowe | Back | 60-day DL. Out for the season |
| Ryan Rowland-Smith | Back | 15-day DL. On Triple-A rehab assignment |
| Carlos Silva | Illness | 15-day DL. Out until at least late August |
| Eric O'Flaherty | Illness | 15-day DL. On Triple-A rehab assignment |
| Erik Bedard | Shoulder | 60-day DL. Out for the season |
| Ian Kinsler | Groin | 15-day DL. Out until at least late August |
| Robinson Tejeda | Biceps | 15-day DL. Out until at least early September |
| Nelson Cruz | Hamstring | 15-day DL. Out until at least early September |
| Milton Bradley | Knee | 15-day DL. Might miss the rest of the season |
| Brandon McCarthy | Shoulder | 60-day DL. Out for the season |
| Michael Young | Neck | Questionable for Aug. 17 at Tampa Bay |
| Martín Prado | Finger | 15-day DL. On Triple-A rehab assignment. Might return for Aug. 17-19 series vs. Washington |
| Chipper Jones | Knee | 15-day DL. Out for the season |
| Matt Treanor | Knee | 15-day DL. On Triple-A rehab assignment |
| Garrett Mock | Neck | 60-day DL. On Class A rehab assignment |
| Jesús Flores | Shoulder | 60-day DL. Might be out for the season |
| Nick Johnson | Wrist | 60-day DL. Out until at least late August |
| Cristian Guzmán | Quadriceps | 15-day DL. Out until at least early September |
| Ross Detwiler | Hip | 15-day DL. Might be out for the season |
| John Maine | Shoulder | 15-day DL. Out for the season |
| Brian Stokes | Shoulder | 15-day DL. On Triple-A rehab assignment |
| Chase Utley | Thumb | 15-day DL. On Class A rehab assignment. Might return for Aug. 17-19 series vs. San Francisco |
| Clay Condrey | Elbow | 60-day DL. Out for the season |
| Jamie Moyer | Elbow | 15-day DL. Out for the season |
| Kris Benson | Shoulder | 60-day DL. On Triple-A rehab assignment |
| Brandon Watson | Kidney | 15-day DL. Out until at least late August |
| Ryan Howard | Ankle | 15-day DL. Eligible to return for Aug. 17-19 series vs. San Francisco |
| Ronny Cedeño | Shoulder | Questionable for Aug. 17 vs. Florida |
| Mark DeRosa | Wrist | 60-day DL. Out for the season |
| Jose Ascanio | Shoulder | 60-day DL. On Class A rehab assignment |
| Derrek Lee | Back | Doubtful for Aug. 17-19 vs. San Diego |
| Geovany Soto | Shoulder | 15-day DL. Out until at least late August |
| Ángel Guzmán | Shoulder | 60-day DL. Out for the season |
| Jeremy Affeldt | Side | 15-day DL. On Class A rehab assignment |
| Jeff Keppinger | Toe | Questionable for Aug. 17-19 vs. N.Y. Mets |
| Johnny Cueto | Suspension | 7-game suspension. Eligible to return for Aug. 21 start at L.A. Dodgers |
| Aaron Harang | Back | 15-day DL. Expected to make Triple-A rehab start Aug. 20 |
| Brian Moehler | Groin | 15-day DL. Might be out for the season |
| Lance Berkman | Ankle | Questionable for Aug. 17 vs. Detroit |
| Felipe Paulino | Shoulder | 60-day DL. Might be out for the season |
| Gabe Kapler | Ankle | 15-day DL. Out until at least late August |
| Jeff Suppan | Groin | 15-day DL. Out until at least late August |
| J.J. Hardy | Wrist | Questionable for Aug. 17-19 series vs. Chicago White Sox |
| Mike Cameron | Abdominal | 15-day DL. Out until at least late August |
| Ben Sheets | Elbow | 60-day DL. Out for the season |
| Nyjer Morgan | Hip | 15-day DL. On Class A rehab assignment. Eligible to return Aug. 19 at Atlanta |
| John Grabow | Knee | 15-day DL. Out for the season |
| Jason Bay | Concussion | 15-day DL. Out until at least late August |
| Dámaso Marte | Shoulder | 15-day DL. Out until at least late August |
| Steve Pearce | Knee | 60-day DL. Out for the season |
| Jack Wilson | Hand | 15-day DL. Out for the season |
| Russ Springer | Hip | 15-day DL. Out until at least early September |
| Anthony Reyes | Elbow | 60-day DL. On Double-A rehab assignment |
| Joel Piñeiro | Oblique | 15-day DL. Out until at least mid-September |
| Jason LaRue | Concussion | 15-day DL. Out until at least late August |
| Dustin Nippert | Head | 15-day DL. Out until at least late August |
| Doug Davis | Elbow | 15-day DL. Out until at least early September |
| Brandon Webb | Shoulder | 60-day DL. Might be out for the season |
| Juan Gutiérrez | Shoulder | 15-day DL. Eligible to return Aug. 18 vs. Cincinnati |
| Alberto Arias | Shoulder | 60-day DL. Out for the season |
| Jeff Francis | Shoulder | 15-day DL. Out until at least late August |
| Aaron Cook | Toe | 15-day DL. Out until at least late August |
| Jeff Baker | Back | Questionable for Aug. 17-19 vs. San Diego |
| Rafael Furcal | Back | 15-day DL. Out until at least late August |
| Russell Martin | Hip | 15-day DL. Out for the season |
| Jon Meloan | Elbow | 60-day DL. Out for the season |
| Brad Penny | Back, shoulder | 15-day DL. Might be out for the season |
| Jake Peavy | Shoulder | 15-day DL. Out for the season |
| Matt Antonelli | Hand | 60-day DL. On Class A rehab assignment |
| Khalil Greene | Hand | 15-day DL. Out until at least late August |
| Erick Threets | Toe | 15-day DL. Out until at least late August |
| Tyler Walker | Shoulder | 15-day DL. Out for the season |
| Tyler Walker | Shoulder | 15-day DL. Out for the season |
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